Overview
Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring hallucinogenic drug that produces effects similar to psilocybin and LSD. The drug is found in certain cacti plants that are native to the southwest United States, Mexico, and South America and include the peyote cactus (Lophophora williamsii), the San Pedro cactus (Trichocereus pachanoi), and the Peruvian Torch cactus (Trichocereus peruvianus).
Native Americans have used mescaline for thousands of years in religious ceremonies and the treatment of various physical ailments. Evidence indicates the use of these cacti in cultural practices dates back at least 5,000 years.1 Although the use of mescaline products is illegal in the United States, peyote is recognized as a sacrament in the Native American Church of North America.
Effects, Potency and dosage
Mescaline’s hallucinogenic effects are caused by the substance’s ability to stimulate serotonin and dopamine receptors in the central nervous systems (CNS).2 Serotonin affects mood, perception, muscle control, and body temperature.3 Dopamine plays a role in the brain’s motivation and reward system.
The effects of mescaline last for 10 to 12 hours, although the use of mescaline as a sacrament takes place over two days.4 As a hallucinogenic or psychedelic drug, mescaline induces an altered state of consciousness where people experience altered thinking and perception. People often describe this state as enjoyable, euphoric, and dreamlike.
Visual hallucinations are a common effect of mescaline use, and people often describe distortions in their experience of time.
Mescaline has a low ability to cross the blood-brain barrier due to its low lipid solubility. Because of this, it requires higher doses of mescaline to produce psychedelic effects similar to other hallucinogens.
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